The Supplement Markup Report

• Across 209 popular supplements, the typical (median) brand product is priced 2.9x its lower-cost, ingredient-matched alternative; the average markup is 5.2x.
• 76% of the supplements analyzed are priced at least 2x the ingredient-matched alternative, and 60 are priced 5x or more.
• The largest single gap is Isagenix IsaLean Shake: about $296/month versus a roughly $70/month ingredient-matched alternative, an estimated $2,712/year in savings.
• The steepest multiple is Amway Nutrilite Double X, priced about 42x its lower-cost ingredient match.
• On average a tracked brand product costs $55/month versus about $18/month for its ingredient-matched alternative.
• In aggregate the 209 brand products would cost about $138,096/year; the ingredient-matched alternatives total about $45,079/year.

Every figure is estimated from public retail prices and derives from the 209 live comparisons on this site. A “lower-cost ingredient match” shares overlapping ingredients and a similar intended use; it is not a medically equivalent product. This is a price comparison, not medical advice.

Ranked by estimated annual overspend versus the ingredient-matched alternative.

Method: for each product we build a specific lower-cost match from public retail data, normalize to a monthly cost, and estimate annual savings. Markup = brand monthly price / match monthly price. Prices change often and are estimates; verify at the merchant. This is a price comparison, not medical advice.